A self-assembling lanthanide molecular nanoparticle for optical imaging

Katherine A. Brown; Xiaoping Yang; Desmond Schipper; Justin W. Hall; Lauren J. DePue; Annie J. Gnanam; Jonathan F. Arambula; Jessica N. Jones; Jagannath Swaminathan; Yakhya Dieye; Jamuna Vadivelu; Don J. Chandler; Edward M. Marcotte; Jonathan L. Sessler; Lauren I. R. Ehrlich; Richard A. Jones

doi:10.1039/C4DT02646B

A self-assembling lanthanide molecular nanoparticle for optical imaging†

Katherine A. Brown,^ab Xiaoping Yang,^c Desmond Schipper,^b Justin W. Hall,^b Lauren J. DePue,^b Annie J. Gnanam,^b Jonathan F. Arambula,^b Jessica N. Jones,^de Jagannath Swaminathan,^ef Yakhya Dieye,^g Jamuna Vadivelu,^g Don J. Chandler,^h Edward M. Marcotte,^def Jonathan L. Sessler,^b Lauren I. R. Ehrlich^de and Richard A. Jones*^b

Author affiliations

* Corresponding authors

^a Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK

^b Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, USA
E-mail: rajones@cm.utexas.edu
Tel: +1 (512) 471 1706

^c College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China

^d Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, USA

^e Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712, USA

^f Center for Systems and Synthetic Biology, The University of Texas at Austin, Austin, Texas 78712, USA

^g Department of Medical Microbiology, University of Malaya, Kuala Lumpur 50603, Malaysia

^h Luminex, Austin, Texas, USA

Abstract

Chromophores that incorporate f-block elements have considerable potential for use in bioimaging applications because of their advantageous photophysical properties compared to organic dye, which are currently widely used. We are developing new classes of lanthanide-based self-assembling molecular nanoparticles as reporters for imaging and as multi-functional nanoprobes or nanosensors for use with biological samples. One class of these materials, which we call lanthanide “nano-drums”, are homogeneous 4d–4f clusters approximately 25 to 30 Å in diameter. These are capable of emitting from the visible to near-infrared wavelengths. Here, we present the synthesis, crystal structure, photophysical properties and comparative cytotoxicity data for a 32 metal Eu-Cd nano-drum [Eu₈Cd₂₄L₁₂(OAc)₄₈] (1). We also explored the imaging capabilities of this nano-drum using epifluorescence, TIRF, and two-photon microscopy platforms.

This article is part of the themed collection: Dalton Discussion 14: Advancing the chemistry of the f-elements

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A self-assembling lanthanide molecular nanoparticle for optical imaging†

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