Issue 1, 2015

Oleic acid content of a meal promotes oleoylethanolamide response and reduces subsequent energy intake in humans

Abstract

Animal data suggest that dietary fat composition may influence endocannabinoid (EC) response and dietary behavior. This study tested the hypothesis that fatty acid composition of a meal can influence the short-term response of ECs and subsequent energy intake in humans. Fifteen volunteers on three occasions were randomly offered a meal containing 30 g of bread and 30 mL of one of three selected oils: sunflower oil (SO), high oleic sunflower oil (HOSO) and virgin olive oil (VOO). Plasma EC concentrations and appetite ratings over 2 h and energy intake over 24 h following the experimental meal were measured. Results showed that after HOSO and VOO consumption the circulating oleoylethanolamide (OEA) was significantly higher than after SO consumption; a concomitantly significant reduction of energy intake was found. For the first time the oleic acid content of a meal was demonstrated to increase the post-prandial response of circulating OEA and to reduce energy intake at subsequent meals in humans.

Graphical abstract: Oleic acid content of a meal promotes oleoylethanolamide response and reduces subsequent energy intake in humans

Article information

Article type
Paper
Submitted
04 Aug 2014
Accepted
30 Sep 2014
First published
01 Oct 2014

Food Funct., 2015,6, 203-209

Author version available

Oleic acid content of a meal promotes oleoylethanolamide response and reduces subsequent energy intake in humans

I. Mennella, M. Savarese, R. Ferracane, R. Sacchi and P. Vitaglione, Food Funct., 2015, 6, 203 DOI: 10.1039/C4FO00697F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements