Issue 18, 2015

Paper diagnostic device for quantitative electrochemical detection of ricin at picomolar levels

Abstract

We report a paper-based assay platform for detection of ricin a chain. The paper platform is assembled by simple origami paper folding. The sensor is based on quantitative, electrochemical detection of silver nanoparticle labels linked to a magnetic microbead support via a ricin immunosandwich. Importantly, ricin was detected at concentrations as low as 34 pM. Additionally, the assay is robust, even in the presence of 100-fold excess hoax materials. Finally, the device is easily remediated after use by incineration. The cost of the device, not including reagents, is just $0.30. The total assay time, including formation of the immunosandwich, is 9.5 min.

Graphical abstract: Paper diagnostic device for quantitative electrochemical detection of ricin at picomolar levels

Supplementary files

Article information

Article type
Paper
Submitted
25 Jun 2015
Accepted
20 Jul 2015
First published
30 Jul 2015

Lab Chip, 2015,15, 3707-3715

Paper diagnostic device for quantitative electrochemical detection of ricin at picomolar levels

J. C. Cunningham, K. Scida, M. R. Kogan, B. Wang, A. D. Ellington and R. M. Crooks, Lab Chip, 2015, 15, 3707 DOI: 10.1039/C5LC00731C

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