Issue 24, 2015
From the journal:

Lab on a Chip

Distinguishing of tumor cell-targeting peptide ligands through a color-encoding microarray†

Zihua Wang,‡a   Weizhi Wang,‡*a   Lingling Genga  and  Zhiyuan Hu*a  

* Corresponding authors

a CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
E-mail: huzy@nanoct.cn, wangwz@nanoctr.cn
Fax: +86 10 82545643
Tel: +86 10 82545643

Abstract

A silicon-based microarray system was constructed to discover the affinity peptides and to distinguish the specific peptides from a high throughput library. Using a color-encoding strategy, in situ peptide distinguishing between HER1 ligands and HER2 ligands was achieved. Novel affinity peptide sequences H1P (HER1 ligand) and H2P (HER2 ligand) were determined with nmol affinity.

Graphical abstract: Distinguishing of tumor cell-targeting peptide ligands through a color-encoding microarray

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Article information

DOI
https://doi.org/10.1039/C5LC01010A
Article type
Communication
Submitted
22 Aug 2015
Accepted
16 Oct 2015
First published
16 Oct 2015

Lab Chip, 2015,15, 4512-4516

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Distinguishing of tumor cell-targeting peptide ligands through a color-encoding microarray

Z. Wang, W. Wang, L. Geng and Z. Hu, Lab Chip, 2015, 15, 4512 DOI: 10.1039/C5LC01010A

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