Histone deacetylases are important drug targets, which are difficult to characterize due to their poor accessibility. We have developed a miniaturized assay for the multi-site readout of deacetylase activity and profiled the substrate selectivity of HDACs for acetylation sites on histone H4 and tumor suppressor protein p53.
J. O. Jost, A. Hanswillemenke and D. Schwarzer, Mol. BioSyst., 2015, 11, 1820 DOI: 10.1039/C5MB00326A
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