Issue 7, 2015
From the journal:

MedChemComm

Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril†‡

Xiaoqing Miao,a   Ye Li,a   Ian Wyman,b   Simon M. Y. Lee,a   Donal H. Macartney,b   Ying Zheng*a  and  Ruibing Wang*a  

* Corresponding authors

a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China
E-mail: yzheng@umac.mo, rwang@umac.mo
Tel: +853 8822 4689

b Department of Chemistry, Queen's University, Kingston, ON, Canada

Abstract

This report describes, for the first time, cucurbit[7]uril-assisted quantitative in vitro and in vivo uptake of a hydrophobic model drug, coumarin-6, by both an epithelial cell model and a zebrafish model. The transcellular delivery pathway study suggested multiple mechanisms involved, including macropinocytosis, clathrin and lipid raft-mediated endocytosis/exocytosis.

Graphical abstract: Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril

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Article information

DOI
https://doi.org/10.1039/C5MD00189G
Article type
Concise Article
Submitted
30 Apr 2015
Accepted
12 Jun 2015
First published
12 Jun 2015
This article is Open Access
Creative Commons BY-NC license

Med. Chem. Commun., 2015,6, 1370-1374

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Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril

X. Miao, Y. Li, I. Wyman, S. M. Y. Lee, D. H. Macartney, Y. Zheng and R. Wang, Med. Chem. Commun., 2015, 6, 1370 DOI: 10.1039/C5MD00189G

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