Issue 4, 2015
From the journal:

Organic & Biomolecular Chemistry

Palladium-catalyzed oxidative cross-coupling of azole-4-carboxylates with indoles: an approach to the synthesis of pimprinine†

Haipin Zhou,a   Kuo Gai,a   Aijun Lin,a   Jinyi Xu,a   Xiaoming Wu*a  and  Hequan Yao*a  

* Corresponding authors

a State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China
E-mail: xmwu@cpu.edu.cn, hyao@cpu.edu.cn
Fax: +86 25-83301606
Tel: +86 25-83271042

Abstract

An efficient and straightforward method for the production of 5-(3-indolyl)azoles incorporating the privileged structures indoles and azoles via palladium-catalyzed double C–H bond cleavage under mild conditions was disclosed. As expected, this protocol provided an easy method for the synthesis of indole alkaloids pimprinine and WS-30581 A in moderate yields.

Graphical abstract: Palladium-catalyzed oxidative cross-coupling of azole-4-carboxylates with indoles: an approach to the synthesis of pimprinine

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Article information

DOI
https://doi.org/10.1039/C4OB01844C
Article type
Paper
Submitted
29 Aug 2014
Accepted
14 Nov 2014
First published
14 Nov 2014

Org. Biomol. Chem., 2015,13, 1243-1248

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Palladium-catalyzed oxidative cross-coupling of azole-4-carboxylates with indoles: an approach to the synthesis of pimprinine

H. Zhou, K. Gai, A. Lin, J. Xu, X. Wu and H. Yao, Org. Biomol. Chem., 2015, 13, 1243 DOI: 10.1039/C4OB01844C

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