Issue 10, 2015
From the journal:

Organic & Biomolecular Chemistry

Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases†

Cátia Parente Carvalho,a   Amir Norouzy,b   Vera Ribeiro,c   Werner M. Naub  and  Uwe Pischel*a  

* Corresponding authors

a CIQSO-Center for Research in Sustainable Chemistry and Department of Chemical Engineering, Physical Chemistry and Organic Chemistry, University of Huelva, Campus El Carmen s/n, E-21071 Huelva, Spain
E-mail: uwe.pischel@diq.uhu.es
Fax: +34 959 21 99 83
Tel: +34 959 21 99 82

b Department of Life Sciences and Chemistry, Jacobs University Bremen, Campus Ring 1, D-28759 Bremen, Germany

c Center for Molecular and Structural Biomedicine, CBME/IBB, LA, University of Algarve, Faculty of Science and Technology, Campus de Gambelas, 8005-139 Faro, Portugal

Abstract

Cucurbiturils (CB6 and CB7) were shown to inhibit the enzymatically catalyzed restriction of plasmids and linear DNA. This effect can be inverted by supramolecular masking of the macrocycles through competitive complexation with polyamines. These experiments provide supramolecular control of biocatalytic processes.

Graphical abstract: Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

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Article information

DOI
https://doi.org/10.1039/C4OB02122C
Article type
Communication
Submitted
04 Oct 2014
Accepted
24 Dec 2014
First published
12 Jan 2015
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2015,13, 2866-2869

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Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

C. Parente Carvalho, A. Norouzy, V. Ribeiro, W. M. Nau and U. Pischel, Org. Biomol. Chem., 2015, 13, 2866 DOI: 10.1039/C4OB02122C

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