Issue 9, 2015
From the journal:

Organic & Biomolecular Chemistry

Direct construction of 2-alkylbenzo-1,3-azoles via C–H activation of alkanes for C–C and C–X (X = O, S) bond formation†

Arvind K. Yadava  and  Lal Dhar S. Yadav*a  

* Corresponding authors

a Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad-211002, India
E-mail: ldsyadav@hotmail.com
Fax: +915322460533
Tel: +91 5322500652

Abstract

Copper catalyzed straightforward synthesis of 2-alkylbenzoxa(thia)azoles from aryl isocyanates/isothiocyanates and simple alkanes is reported. The protocol utilizes ditertiary butyl peroxide (DTBP) as a radical initiator and involves sequential formation of C–C and C–X (X = O, S) bonds followed by aromatization in a one-pot procedure.

Graphical abstract: Direct construction of 2-alkylbenzo-1,3-azoles via C–H activation of alkanes for C–C and C–X (X = O, S) bond formation

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4OB02488E
Article type
Paper
Submitted
26 Nov 2014
Accepted
23 Dec 2014
First published
24 Dec 2014

Org. Biomol. Chem., 2015,13, 2606-2611

Permissions

Request permissions

Direct construction of 2-alkylbenzo-1,3-azoles via C–H activation of alkanes for C–C and C–X (X = O, S) bond formation

A. K. Yadav and L. D. S. Yadav, Org. Biomol. Chem., 2015, 13, 2606 DOI: 10.1039/C4OB02488E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements