Issue 14, 2015

Strategically designed biomodel: engineering C3–C4 cleavage of d-fructose

Abstract

Amongst a library of aldolase inspired, rationally designed compounds, the acridine derivative carrying a (S)-Tyr-Gly-(S)-Lys tripeptide selectively effected C3–C4 scissoring of D-fructose and produced D-glyceraldehyde and dihydroxyacetone.

Graphical abstract: Strategically designed biomodel: engineering C3–C4 cleavage of d-fructose

Supplementary files

Article information

Article type
Paper
Submitted
24 Dec 2014
Accepted
19 Feb 2015
First published
19 Feb 2015

Org. Biomol. Chem., 2015,13, 4210-4220

Strategically designed biomodel: engineering C3–C4 cleavage of D-fructose

P. Singh, A. Kumar, S. Kaur and A. Singh, Org. Biomol. Chem., 2015, 13, 4210 DOI: 10.1039/C4OB02666G

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