A practical synthesis of novel tryptamine-based macrocycles using an Ugi 4-CR/click-cycloaddition sequential reaction protocol is described. The main features of the macrocyclic scaffolds are a peptoid moiety, a 1,3-substituted indole nucleus, and a triazole ring.
L. Chavez-Acevedo and L. D. Miranda, Org. Biomol. Chem., 2015, 13, 4408 DOI: 10.1039/C5OB00067J
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