Issue 22, 2015
From the journal:

Organic & Biomolecular Chemistry

Scalable synthesis of the unusual amino acid segment (ADMOA unit) of marine anti-inflammatory peptide: solomonamide A†

Nerella Kavithaa  and  Srivari Chandrasekhar*a  

* Corresponding authors

a Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India
E-mail: srivaric@iict.res.in
Fax: +91-40-27160152
Tel: +91-40-27193210, 27193434

Abstract

The most abundantly available hexose sugar, D-glucose has been converted to protected 4-amino(2′amino-4′-hydroxy phenyl)-3,5-dihydroxy-2-methyl-6-oxo hexanoic acid (protected ADMOA, 3), the unusual amino acid present in marine natural product solomonamide A in gram quantities involving easy to operate chemical transformations.

Graphical abstract: Scalable synthesis of the unusual amino acid segment (ADMOA unit) of marine anti-inflammatory peptide: solomonamide A

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Article information

DOI
https://doi.org/10.1039/C5OB00481K
Article type
Paper
Submitted
11 Mar 2015
Accepted
23 Apr 2015
First published
23 Apr 2015

Org. Biomol. Chem., 2015,13, 6242-6248

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Scalable synthesis of the unusual amino acid segment (ADMOA unit) of marine anti-inflammatory peptide: solomonamide A

N. Kavitha and S. Chandrasekhar, Org. Biomol. Chem., 2015, 13, 6242 DOI: 10.1039/C5OB00481K

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