Issue 47, 2015
From the journal:

Organic & Biomolecular Chemistry

TBHP/TFA mediated oxidative cross-dehydrogenative coupling of N-heterocycles with aldehydes†

Jiayu Chen,‡ab   Miao Wan,‡a   Jing Hua,c   Yi Sun,ab   Zheng Lv,b   Wei Li*b  and  Lei Liu*ac  

* Corresponding authors

a School of Pharmaceutical Sciences, Jinan 250012, P. R. China
E-mail: leiliu@sdu.edu.cn

b Department of Pharmaceutical Analysis, School of Pharmacy, Shandong University of Traditional Chinese Medicine, Shandong 250355, China
E-mail: liwei6911@163.com

c Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University), Ministry of Education of China, Guilin 541004, China

Abstract

An effective and metal-free oxidative cross-dehydrogenative coupling (CDC) of N-heterocycles with diverse aldehydes has been established in the presence of TBHP/TFA. The scope with respect to aldehyde and N-heterocycle components is broad, allowing facile synthesis of a broad range of structurally diverse C1-acyl substituted heterocycles in good efficiency.

Graphical abstract: TBHP/TFA mediated oxidative cross-dehydrogenative coupling of N-heterocycles with aldehydes

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Article information

DOI
https://doi.org/10.1039/C5OB01763G
Article type
Paper
Submitted
22 Aug 2015
Accepted
30 Sep 2015
First published
01 Oct 2015

Org. Biomol. Chem., 2015,13, 11561-11566

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TBHP/TFA mediated oxidative cross-dehydrogenative coupling of N-heterocycles with aldehydes

J. Chen, M. Wan, J. Hua, Y. Sun, Z. Lv, W. Li and L. Liu, Org. Biomol. Chem., 2015, 13, 11561 DOI: 10.1039/C5OB01763G

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