Synthesis and characterization of valproic acid ester pro-drug micelles via an amphiphilic polycaprolactone block copolymer design

Abstract

The attachment of Histone deacetylase (HDAC) inhibitors via covalent bonds to biocompatible and biodegradable block copolymers provides a new research direction for cancer treatment. Herein, we report the synthesis and characterization of valproic acid ester pro-drug micelles of amphiphilic polycaprolactone block copolymers and their potential applications in drug delivery.