Transition-metal free oxidative aliphatic C–H fluorination

Abstract

A practical and highly selective fluorination of unactivated aliphatic C–H bonds without the use of transition metals has been developed. This C–H fluorination protocol is robust, operationally simple, scalable and compatible with moisture and air. Furthermore, the method exhibits a broad substrate scope and is applicable to late-stage fluorination of natural products and derivatives, which make it a valuable method for the synthesis of fluorinated complex molecules.