Copper-mediated oxidative difluoromethylation of terminal alkynes with TMSCF2H

Sheng-Qing Zhu; Xiu-Hua Xu; Feng-Ling Qing

doi:10.1039/C5QO00186B

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Copper-mediated oxidative difluoromethylation of terminal alkynes with TMSCF₂H†

Sheng-Qing Zhu,^a Xiu-Hua Xu^a and Feng-Ling Qing*^ab

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* Corresponding authors

^a Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China
E-mail: flq@mail.sioc.ac.cn

^b College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai 201620, China

Abstract

A copper-mediated oxidative difluoromethylation of terminal alkynes using nucleophilic TMSCF₂H in the presence of an oxidant 9,10-phenanthraquinone was developed. This reaction provided a direct and efficient method for preparation of difluoromethylated alkynes.

This article is part of the themed collections: Celebrating 70 Years of Shanghai Institute of Organic Chemistry and HOT articles in Organic Chemistry Frontiers in 2015

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Article information

DOI: https://doi.org/10.1039/C5QO00186B
Article type: Research Article
Submitted: 11 Jun 2015
Accepted: 27 Jun 2015
First published: 29 Jun 2015

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Org. Chem. Front., 2015,2, 1022-1025

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Copper-mediated oxidative difluoromethylation of terminal alkynes with TMSCF₂H

S. Zhu, X. Xu and F. Qing, Org. Chem. Front., 2015, 2, 1022 DOI: 10.1039/C5QO00186B

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