Synthesis and in vitro phantom NMR and MRI studies of fully organic free radicals, TEEPO-glucose and TEMPO-glucose, potential contrast agents for MRI

M. Soikkeli; K. Sievänen; J. Peltonen; T. Kaasalainen; M. Timonen; P. Heinonen; S. Rönkkö; V.-P. Lehto; J. S. Kavakka; S. Heikkinen

doi:10.1039/C4RA11455H

Synthesis and in vitro phantom NMR and MRI studies of fully organic free radicals, TEEPO-glucose and TEMPO-glucose, potential contrast agents for MRI†

M. Soikkeli,^a K. Sievänen,^a J. Peltonen,^b T. Kaasalainen,^b M. Timonen,^b P. Heinonen,^a S. Rönkkö,^c V.-P. Lehto,^c J. S. Kavakka^a and S. Heikkinen*^a

Author affiliations

* Corresponding authors

^a Laboratory of Organic Chemistry, Department of Chemistry, University of Helsinki, P.O. Box 55, FIN-00014 University of Helsinki, Finland
E-mail: Sami.Heikkinen@helsinki.fi

^b HUS Helsinki Medical Imaging Center, P.O. Box 340, FIN-00029 HUS, Helsinki, Finland

^c Department of Applied Physics, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio, Finland

Abstract

Two organic radical contrast agents, TEMPO-Glc and TEEPO-Glc, were synthesized and their stabilities and contrast enhancing properties were tested with in vitro NMR and MRI experiments. Owing to the glucose moieties in the prepared compounds, this study presents potential candidates for a tumor targeting fully organic contrast agents for MRI.

RSC Advances

Synthesis and in vitro phantom NMR and MRI studies of fully organic free radicals, TEEPO-glucose and TEMPO-glucose, potential contrast agents for MRI†

Abstract

Supplementary files

Article information

Download Citation

Author version available

Permissions

Synthesis and in vitro phantom NMR and MRI studies of fully organic free radicals, TEEPO-glucose and TEMPO-glucose, potential contrast agents for MRI

Social activity

Search articles by author

Spotlight

Advertisements