Issue 9, 2015
From the journal:

RSC Advances

A practical, catalytic and selective deprotection of a Boc group in N,N′-diprotected amines using iron(iii)-catalysis†

Juan M. López-Soria,a   Sixto J. Pérez,a   J. Nicolás Hernández,a   Miguel A. Ramírez,a   Víctor S. Martín*a  and  Juan I. Padrón*ab  

* Corresponding authors

a Instituto Universitario de Bio-Orgánica “Antonio González”, CIBICAN, Universidad de La Laguna, Avda. Astrofísico Francisco Sánchez 2, La Laguna, Tenerife, Spain
E-mail: vmartin@ull.es
Fax: +34 922 318 571

b Instituto de Productos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas (CSIC), Avda. Astrofísico Francisco Sánchez 3, La Laguna, Tenerife, Spain
E-mail: jipadron@ipna.csic.es
Fax: +34 922260135

Abstract

A selective, catalytic and practical method for removing a Boc group from several N,N′-diprotected amino acids and amine derivatives using iron(III) salts as sustainable catalysts is described. The process is clean, not needing a purification step. A theoretical study rationalizing the results with several metals is presented.

Graphical abstract: A practical, catalytic and selective deprotection of a Boc group in N,N′-diprotected amines using iron(iii)-catalysis

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Article information

DOI
https://doi.org/10.1039/C4RA12143K
Article type
Communication
Submitted
10 Oct 2014
Accepted
16 Dec 2014
First published
17 Dec 2014

RSC Adv., 2015,5, 6647-6651

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A practical, catalytic and selective deprotection of a Boc group in N,N′-diprotected amines using iron(III)-catalysis

J. M. López-Soria, S. J. Pérez, J. N. Hernández, M. A. Ramírez, V. S. Martín and J. I. Padrón, RSC Adv., 2015, 5, 6647 DOI: 10.1039/C4RA12143K

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