Issue 3, 2015
From the journal:

RSC Advances

A europium–lipoprotein nanocomposite for highly-sensitive MR-fluorescence multimodal imaging†

Qi Wang,a   Shizhen Chen,a   Qing Luo,a   Maili Liua  and  Xin Zhou*a  

* Corresponding authors

a Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China
E-mail: xinzhou@wipm.ac.cn

Abstract

A novel reconstituted high-density lipoprotein (rHDL) nanocomposite has been prepared for highly-sensitive magnetic resonance (MR)-fluorescence multimodal imaging. Such a nanocomposite is able to enhance the MR sensitivity up to 129 fold in comparison to the traditional small molecule MRI agent based on paramagnetic chemical exchange saturation transfer (PARACEST). It has also demonstrated specific targeting to macrophage cells, which shows great potential for the detection of atherosclerosis.

Graphical abstract: A europium–lipoprotein nanocomposite for highly-sensitive MR-fluorescence multimodal imaging

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Article information

DOI
https://doi.org/10.1039/C4RA12201A
Article type
Communication
Submitted
11 Oct 2014
Accepted
28 Nov 2014
First published
28 Nov 2014

RSC Adv., 2015,5, 1808-1811

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A europium–lipoprotein nanocomposite for highly-sensitive MR-fluorescence multimodal imaging

Q. Wang, S. Chen, Q. Luo, M. Liu and X. Zhou, RSC Adv., 2015, 5, 1808 DOI: 10.1039/C4RA12201A

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