Issue 39, 2015
From the journal:

RSC Advances

Enzymatic formation of a meta-stable supramolecular hydrogel for 3D cell culture†

Guoqin Chen,‡a   Jiaxin Chen,‡b   Qicai Liu,b   Caiwen Ou*c  and  Jie Gao*d  

* Corresponding authors

a Cardiovascular Medicine Department of Central Hospital of Panyu District and Cardiovascular Institute of Panyu District, Guangzhou 511400, P. R. China

b Experimental Medical Research Center, Guangzhou Medical University, Guangzhou 510182, P. R. China

c Key Laboratory of Construction and Detection of Guangdong Province, Southern Medical University, Guangzhou 510280, P. R. China
E-mail: 1284572007@qq.com

d State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, P. R. China
E-mail: chemgaojie@nankai.edu.cn

Abstract

We report the phosphatase-triggered formation of a meta-stable peptide-based supramolecular hydrogel that can easily change to a clear solution by mechanical forces. Cells cultured in the hydrogel can therefore be separated by pipetting followed by centrifugation.

Graphical abstract: Enzymatic formation of a meta-stable supramolecular hydrogel for 3D cell culture

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Article information

DOI
https://doi.org/10.1039/C5RA02449H
Article type
Communication
Submitted
08 Feb 2015
Accepted
19 Mar 2015
First published
19 Mar 2015

RSC Adv., 2015,5, 30675-30678

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Enzymatic formation of a meta-stable supramolecular hydrogel for 3D cell culture

G. Chen, J. Chen, Q. Liu, C. Ou and J. Gao, RSC Adv., 2015, 5, 30675 DOI: 10.1039/C5RA02449H

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