Synthesis and characterization of fluconazole-functionalized magnetic nanoparticles as a catalyst for the synthesis of 3-aryl and 3-amino-imidazo[1,2-a]pyridines

Abstract

Fluconazole was successfully immobilized on the surface of chloropropyl-modified Fe₃O₄–SiO₂ core–shell nanoparticles and was found to exhibit unique catalytic activity for the synthesis of 3-aryl-imidazo[1,2-a]pyridines in water. This catalyst also showed great activity in a multi-component reaction for the synthesis of 3-amino-imidazo[1,2-a]pyridines under solvent-free conditions. The magnetically-recoverable catalyst was found to be capable of repeated reuse without significant loss of activity.