Development of crystalline–amorphous parylene C structure in micro- and nano-range towards enhanced biocompatibility: the importance of oxygen plasma treatment time

Abstract

The crystalline–amorphous parylene C structure was fabricated by Chemical Vapour Deposited (CVD) and functionalised in the micro- and nano-range with the oxygen plasma treatment. The evolution of thermal stability, structure and surface biocompatibility of parylene C films as an effect of oxygen plasma treatment time were evaluated by means of thermogravimetric/differential thermal analysis (TG/DTA), X-Ray Diffraction (XRD) and cells adhesion tests (crystal violet assay, fluorescence microscopy). The results are epitomized by a crystalline–amorphous parylene C structural model. It was found that the time of oxygen plasma treatment is critical for adhesion of osteoblast cells with the optimum of 5–8 minutes.