Issue 67, 2015
From the journal:

RSC Advances

Application of a novel small scale UV LED photochemical batch reactor for the thiol-yne reaction†

Nils Griebenow,*a   Stefan Bräsebc  and  Alica M. Dilmacb  

* Corresponding authors

a Bayer HealthCare Pharmaceuticals AG, Global Drug Discovery, Medicinal Chemistry, Aprather Weg 18a, 42133 Wuppertal, Germany
E-mail: nils.griebenow@bayer.com

b Institute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany

c Institute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen, Germany

Abstract

The application of a novel small scale UV LED photochemical batch reactor for the thiol-yne click reaction was investigated. Optimization of the reaction conditions yielded high conversions. Finally, the methodology could be successfully expanded to the one pot insertion of functionalized alkynes into the disulfide bond of a cysteine derivative.

Graphical abstract: Application of a novel small scale UV LED photochemical batch reactor for the thiol-yne reaction

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Article information

DOI
https://doi.org/10.1039/C5RA08787B
Article type
Paper
Submitted
11 May 2015
Accepted
12 Jun 2015
First published
22 Jun 2015

RSC Adv., 2015,5, 54301-54303

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Application of a novel small scale UV LED photochemical batch reactor for the thiol-yne reaction

N. Griebenow, S. Bräse and A. M. Dilmac, RSC Adv., 2015, 5, 54301 DOI: 10.1039/C5RA08787B

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