Synthesis of functionalized 1,2,3-triazoles using Bi2WO6 nanoparticles as efficient and reusable heterogeneous catalyst in aqueous medium

Abstract

Synthesis of functionalized triazoles is reported via Bi₂WO₆ nanoparticle (10 mol%) mediated 1,3-dipolar cycloaddition reactions of β-nitrostyrenes, phenylacetylene and chalcones with azides (80 °C, 2–6 h) in water. The regioselective formation of 1,4-disubstituted triazoles was achieved in 5–20 minutes using azides and alkynes in presence of CuSO₄·5H₂O (2 mol%), sodium ascorbate (10 mol%) and Bi₂WO₆ nanoparticles (10 mol%) at room temperature in water. Similarly, regioselective synthesis of 1,4,5-trisubstituted triazoles was achieved from chalcones in aqueous medium.