Issue 70, 2015
From the journal:

RSC Advances

Asymmetric transfer hydrogenation of α-amino β-keto ester hydrochlorides through dynamic kinetic resolution†

Pierre-Georges Echeverria,a   Johan Cornil,b   Charlène Férard,a   Amandine Guérinot,b   Janine Cossy,b   Phannarath Phansavath*a  and  Virginie Ratovelomanana-Vidal*a  

* Corresponding authors

a Institut de Recherche de Chimie Paris. Chimie ParisTech, CNRS, PSL Research University, 11 rue Pierre et Marie Curie, 75005 Paris, France
E-mail: phannarath.phansavath@chimie-paristech.fr, virginie.vidal@chimie-paristech.fr

b Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231, ESPCI ParisTech, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France

Abstract

The development of Ru-catalyzed asymmetric transfer hydrogenation of α-amino β-keto ester hydrochlorides is described. The reaction proceeds through dynamic kinetic resolution to afford anti β-hydroxy α-amino esters with good diastereomeric ratios and high enantioselectivities.

Graphical abstract: Asymmetric transfer hydrogenation of α-amino β-keto ester hydrochlorides through dynamic kinetic resolution

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Article information

DOI
https://doi.org/10.1039/C5RA10385A
Article type
Communication
Submitted
01 Jun 2015
Accepted
23 Jun 2015
First published
23 Jun 2015

RSC Adv., 2015,5, 56815-56819

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Asymmetric transfer hydrogenation of α-amino β-keto ester hydrochlorides through dynamic kinetic resolution

P. Echeverria, J. Cornil, C. Férard, A. Guérinot, J. Cossy, P. Phansavath and V. Ratovelomanana-Vidal, RSC Adv., 2015, 5, 56815 DOI: 10.1039/C5RA10385A

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