Issue 82, 2015

Iodine catalysed intramolecular C(sp3)–H functionalization: synthesis of 2,5-disubstituted oxazoles from N-arylethylamides

Abstract

Iodine catalyzed synthesis of 2,5-disubstituted oxazoles from N-arylethylamides through intramolecular C(sp3)–H functionalization under metal-free conditions is described. The method is tolerable to a wide range of substrates having a variety of functional groups with moderate to good yields of the products.

Graphical abstract: Iodine catalysed intramolecular C(sp3)–H functionalization: synthesis of 2,5-disubstituted oxazoles from N-arylethylamides

Supplementary files

Article information

Article type
Communication
Submitted
09 Jul 2015
Accepted
28 Jul 2015
First published
28 Jul 2015

RSC Adv., 2015,5, 66718-66722

Iodine catalysed intramolecular C(sp3)–H functionalization: synthesis of 2,5-disubstituted oxazoles from N-arylethylamides

S. Samanta, R. R. Donthiri, M. Dinda and S. Adimurthy, RSC Adv., 2015, 5, 66718 DOI: 10.1039/C5RA13441B

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