Issue 80, 2015

Metal-free C–N cross-coupling of electrophilic compounds and N-haloimides

Abstract

When DBU is added, the cross-coupling reaction between alkyl halides (halogen = Cl, Br and I) and N-haloimides (halogen = Cl, Br) occurs, resulting in the formation of aminated products. A halogen bond activated nucleophilic substitution mechanism was proposed. The methodology represents an elegant example of applying the halogen bond activation strategy in an organic transformation.

Graphical abstract: Metal-free C–N cross-coupling of electrophilic compounds and N-haloimides

Supplementary files

Article information

Article type
Communication
Submitted
13 Jul 2015
Accepted
27 Jul 2015
First published
27 Jul 2015

RSC Adv., 2015,5, 65600-65603

Metal-free C–N cross-coupling of electrophilic compounds and N-haloimides

L. Zhang, Y. Li, L. Jin and F. Liang, RSC Adv., 2015, 5, 65600 DOI: 10.1039/C5RA13708J

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