Starch–borate–graphene oxide nanocomposites as highly efficient targeted antitumor drugs

Rumei Cheng; Shengju Ou; Yexu Bu; Xuan Li; Xiaohong Liu; Yuqin Wang; Rui Guo; Bingyang Shi; Dayong Jin; Yong Liu

doi:10.1039/C5RA17622K

Starch–borate–graphene oxide nanocomposites as highly efficient targeted antitumor drugs†

Rumei Cheng,^a Shengju Ou,^b Yexu Bu,^a Xuan Li,^a Xiaohong Liu,^a Yuqin Wang,^a Rui Guo,^a Bingyang Shi,^c Dayong Jin

*^cd and Yong Liu*^ac

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* Corresponding authors

^a Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
E-mail: yongliu1980@hotmail.com

^b Nanjing Landa Femtosecond Insepection Techonlogy Co. Ltd., Nanjing High-tech Industry Development Zone, Nanjing, Jiangsu 210032, China

^c ARC Center of Excellence for Nanoscale BioPhotonics, Department of Chemistry and Biomolecular Science, Macquarie University, Sydney, NSW 2109, Australia

^d Institute for Biomedical Materials and Devices, Faculty of Science, University of Technology Sydney, NSW 2007, Australia
E-mail: dayong.jin@uts.edu.au

Abstract

We synthesized novel borate antitumor drugs sourced from starch–borate–graphene oxide (SBG) nanocomposites. In vitro results suggest that SBG from the molar ratio of n_starch : n_borate : n_GO at 2 : 1 : 1 exhibits excellent biocompatibility with normal human cells (>90% cell viability), but are highly toxic against cancer cells (<20% cell viability).

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Starch–borate–graphene oxide nanocomposites as highly efficient targeted antitumor drugs†

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