A two-step continuous flow synthesis of amides from alcohol using a metal-free catalyst

Abstract

Metal-free oxidative amination of aromatic alcohols in the presence of TBHP provides convenient access to amides in 86–96% yield under mild reaction conditions within 15 min in a two-step continuous flow reactor system. This method avoids expensive transition metal catalysts and integrates alcohol oxidation and amide bond formation, which are usually accomplished separately, into a single operation.