KOtBu-promoted synthesis of multi-substituted 4-aminopyrimidines from benzonitriles and aliphatic amides

Abstract

Multi-substituted 4-aminopyrimidines have been prepared from commercially-available benzonitriles and aliphatic amides under transition-metal-free conditions. With KO^tBu as the only promoter, the desired pyrimidines were isolated in moderate to excellent yields.