Issue 7, 2015
From the journal:

Chemical Science

Hyperpolarization of amino acid derivatives in water for biological applications†

S. Glöggler,a   S. Wagnerb  and  L.-S. Bouchard*acd  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, California 90095-1569, USA
E-mail: bouchard@chem.ucla.edu

b Biomedical Imaging Research Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Davis Building G149E, Los Angeles, California 90048-1804, USA

c California NanoSystems Institute, 570 Westwood Plaza, Building 114, Los Angeles, California 90095-1569, USA

d Department of Bioengineering, University of California at Los Angeles, 420 Westwood Plaza, RM 5121 Engineering V, P.O. Box 951600, Los Angeles, California 90095-1569, USA

Abstract

We report on the successful synthesis and hyperpolarization of N-unprotected α-amino acid ethyl propionate esters and extensively, on an alanine derivative hyperpolarized by PHIP (4.4 ± 1.0% 13C-polarization), meeting required levels for in vivo detection. Using water as solvent increases biocompatibility and the absence of N-protection is expected to maintain biological activity.

Graphical abstract: Hyperpolarization of amino acid derivatives in water for biological applications

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Article information

DOI
https://doi.org/10.1039/C5SC00503E
Article type
Edge Article
Submitted
10 Feb 2015
Accepted
07 May 2015
First published
26 May 2015
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2015,6, 4261-4266

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Hyperpolarization of amino acid derivatives in water for biological applications

S. Glöggler, S. Wagner and L.-S. Bouchard, Chem. Sci., 2015, 6, 4261 DOI: 10.1039/C5SC00503E

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