Issue 7, 2015

ATP-triggered biomimetic deformations of bioinspired receptor-containing polymer assemblies

Abstract

Designing synthetic polymer assemblies that can sense a biological signal to mimic cell activities is elusive. We develop a class of block copolymer containing bioinspired host units as supramolecular catchers for the highly-selective capture of adenosine-5′-triphosphate (ATP). Driven by ATP, these block copolymers undergo a stepwise self-assembly and exhibit cascading deformation into highly-ordered nanostructures via the specific recognition effect between ATP and the receptor. By modulating the ATP concentration, one can precisely control the biomimetic evolution of these assemblies in diverse dimensionalities and geometries, like certain organellar deformations. Moreover, the ATP/polymer hybrid aggregates can be reversibly disassembled in response to phosphatase. The special ability of the artificial assemblies to sense intracellular bioactivators can offer new insight into bio-responsive nanomaterials for cellular applications.

Graphical abstract: ATP-triggered biomimetic deformations of bioinspired receptor-containing polymer assemblies

Supplementary files

Article information

Article type
Edge Article
Submitted
17 Mar 2015
Accepted
07 May 2015
First published
07 May 2015
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2015,6, 4343-4349

Author version available

ATP-triggered biomimetic deformations of bioinspired receptor-containing polymer assemblies

Q. Yan and Y. Zhao, Chem. Sci., 2015, 6, 4343 DOI: 10.1039/C5SC00965K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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