Issue 12, 2015

Endogenous signalling control of cell adhesion by using aptamer functionalized biocompatible hydrogel

Abstract

Design of biological signal-responsive biomaterials is essential for controlling cell–cell and cell–matrix interactions. Herein, we developed a dynamic hydrogel to control cell adhesion with biological signals in a cellular microenvironment. The basic principle was based on using nucleic acid aptamer to recognize cell signalling and control the display of bioligands on the hydrogel. Not only exogenous signalling but also endogenous signalling secreted by surrounding cells could activate the dynamic scaffold and tune the cell adhesion state. Since diverse aptamers have been developed, our design can be extended to multiple biological inputs. The biochemical signal-responsive system will greatly enhance the understanding of complex biological processes as well as the ability to manipulate cellular behaviors.

Graphical abstract: Endogenous signalling control of cell adhesion by using aptamer functionalized biocompatible hydrogel

Supplementary files

Article information

Article type
Edge Article
Submitted
15 Jul 2015
Accepted
26 Aug 2015
First published
27 Aug 2015
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2015,6, 6762-6768

Author version available

Endogenous signalling control of cell adhesion by using aptamer functionalized biocompatible hydrogel

W. Li, J. Wang, J. Ren and X. Qu, Chem. Sci., 2015, 6, 6762 DOI: 10.1039/C5SC02565F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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