Multi-biofunctionalization of a titanium surface with a mixture of peptides to achieve excellent antimicrobial activity and biocompatibility

Abstract

In this paper, we developed a method for covalent multi-biofunctionalization of a titanium surface with mixtures of peptides at any desired ratios using click chemistry. We demonstrated that the optimization of the types and ratios of the peptides on a titanium surface resulted in an excellent antimicrobial activity as well as good biocompatibility.