Fluorescent polymeric nanoparticles with ultra-low CMC for cell imaging

Abstract

A novel amphiphilic copolymer is facilely prepared through radical polymerization and subsequent ring-opening crosslinking based on poly(ethylene glycol) monomethyl ether methacrylate, glycidyl methacrylate, and amino-terminated aggregation-induced emission dye. Such a cross-linked polymer can self-assemble into nanoparticles with ultra-low critical micelle concentration (CMC), intense red fluorescence, and excellent biocompatibility for cell imaging.