s-Triazine-based biocompatible hyperbranched epoxy adhesive with antibacterial attributes for sutureless surgical sealing

Abstract

Endeavors have been made over last few decades to relieve mankind from painful suturing during surgery, especially in the case of pediatrics. A few surgical sealants or tissue adhesives have been designed; however, biocompatibility and degradation concerns limit their use. Herein, an s-triazine-based hyperbranched epoxy, along with a poly(amido amine) hardener, was used to develop a highly biocompatible surgical sealant. The epoxy can be cross-linked up to 62% at room temperature. Furthermore, the sealant exhibited antibacterial activity against Staphylococcus aureus, the most notorious microorganism that causes surgical site infections. The sealant is degradable under physiological conditions and the degraded products are non-toxic. Thus, here we demonstrate the major merits of the present sealant such as high mechanical stability, optimum balance between strength and flexibility, biocompatibility and degradability.