Radioactive lutetium metallofullerene 177LuxLu(3−x)N@C80–PCBPEG derivative: a potential tumor-targeted theranostic agent

Guoqiang Zhang; Zhizhong Sun; Hongtao Song; Mingming Zhen; Mirong Guan; Taiwei Chu; Shunzhong Luo; Chunru Wang; Chunying Shu

doi:10.1039/C5TB00983A

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Radioactive lutetium metallofullerene ¹⁷⁷Lu_xLu_(3−x)N@C₈₀–PCBPEG derivative: a potential tumor-targeted theranostic agent†

Guoqiang Zhang,^a Zhizhong Sun,^b Hongtao Song,^b Mingming Zhen,^a Mirong Guan,^a Taiwei Chu,^c Shunzhong Luo,*^b Chunru Wang^a and Chunying Shu*^a

Author affiliations

* Corresponding authors

^a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: shucy@iccas.ac.cn

^b Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621900, China

^c Beijing National Laboratory for Molecular Sciences, Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

Abstract

A radioactive metallofullerene ¹⁷⁷Lu_xLu_(3−x)N@C₈₀ was firstly synthesized by means of neutron irradiation on Lu₃N@C₈₀. After modification by methoxypolyethylene glycol amine, in vivo investigation on tumor-bearing mice was performed. The results reveal favorable affinity toward tumors, suggesting that the obtained ¹⁷⁷Lu_xLu_(3−x)N@C₈₀–PCBPEG could be promising for tumor diagnosis and therapy.

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Article information

DOI: https://doi.org/10.1039/C5TB00983A
Article type: Communication
Submitted: 22 May 2015
Accepted: 01 Aug 2015
First published: 07 Aug 2015

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J. Mater. Chem. B, 2015,3, 7011-7013

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Radioactive lutetium metallofullerene ¹⁷⁷Lu_xLu_(3−x)N@C₈₀–PCBPEG derivative: a potential tumor-targeted theranostic agent

G. Zhang, Z. Sun, H. Song, M. Zhen, M. Guan, T. Chu, S. Luo, C. Wang and C. Shu, J. Mater. Chem. B, 2015, 3, 7011 DOI: 10.1039/C5TB00983A

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Journal of Materials Chemistry B