Issue 39, 2015

Self-assembly of bi-functional peptides on large-pore mesoporous silica nanoparticles for miRNA binding and delivery

Abstract

Bi-functional peptides were designed to have binding abilities for both silica nanoparticles and miRNAs. Non-covalent self-assembly of peptides on large pore mesoporous silica nanoparticles provides a delivery system that shows a high binding capacity for nucleic acids, strong transfection efficiency of miRNA and attractive down-regulation of protein expression.

Graphical abstract: Self-assembly of bi-functional peptides on large-pore mesoporous silica nanoparticles for miRNA binding and delivery

Supplementary files

Article information

Article type
Communication
Submitted
12 Jun 2015
Accepted
09 Sep 2015
First published
11 Sep 2015

J. Mater. Chem. B, 2015,3, 7653-7657

Self-assembly of bi-functional peptides on large-pore mesoporous silica nanoparticles for miRNA binding and delivery

J. Lu, H. Shen, Z. Wu, B. Wang, D. Zhao and L. He, J. Mater. Chem. B, 2015, 3, 7653 DOI: 10.1039/C5TB01133G

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