Sugar based nanotube assembly for the construction of sonication triggered hydrogel: an application of the entrapment of tetracycline hydrochloride

Abstract

A sugar functionalized naphthalimide derivative (H1) self-assembles into supramolecular nanotubes (25 nm pore diameter) by the reaction of 4-N-ethylaminenaphthalimide-N-propinyl and delta-gluconolactone in refluxed ethanol. The suspension of the tube assembly in water can directly form hydrogels when triggered by sonication, without change in morphology or molecular aggregates in the pH range of 5–8. Modified with aminocarproic acid, H2 with more hydrogen bonding sites can form pH tolerant hydrogels in the widest range of pH values from 1–14 accelerated by sonication. The gelation mechanism was studied in detail. To the best of our knowledge, this is the first paradigm wherein hydrogels were constructed from naphthalimide derivatives. Finally, the potential of the hydrogel as a drug delivery and release system for hydrophilic medicine was explored.