Issue 5, 2016
From the journal:

Biomaterials Science

Mesomeric configuration makes polyleucine micelle an optimal nanocarrier†

Taoyuan He,a   Di Li,b   Yanan Yang,*a   Jianxun Ding, ORCID logo *b   Feng Jin,b   Xiuli Zhuangb  and  Xuesi Chenb  

* Corresponding authors

a Department of Chemical Engineering, Changchun University of Technology, Changchun 130012, P. R. China
E-mail: yangyanan@ccut.edu.cn

b Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
E-mail: jxding@ciac.ac.cn

Abstract

Micelle with mesomeric polyleucine (PDLLeu) core demonstrated the most uniform morphology, the smallest diameter and the highest drug loading capability compared to those with dextrorotatory (PDLeu), levorotatory (PLLeu) and racemic PLeu (PD/LLeu) cores. In addition, the modification with c(RGDfC) endowed the optimal PDLLeu micelle with enhanced intracellular drug release and cytotoxicity, indicating its great potential for targeted drug delivery.

Graphical abstract: Mesomeric configuration makes polyleucine micelle an optimal nanocarrier

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Article information

DOI
https://doi.org/10.1039/C6BM00022C
Article type
Communication
Submitted
14 Jan 2016
Accepted
08 Feb 2016
First published
15 Feb 2016

Biomater. Sci., 2016,4, 814-818

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Mesomeric configuration makes polyleucine micelle an optimal nanocarrier

T. He, D. Li, Y. Yang, J. Ding, F. Jin, X. Zhuang and X. Chen, Biomater. Sci., 2016, 4, 814 DOI: 10.1039/C6BM00022C

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