Issue 9, 2016
From the journal:

Biomaterials Science

Biophysical and chemical handles to control the size of DNA nanoparticles produced by rolling circle amplification†

So Yeon Lee,‡ab   Kyoung-Ran Kim,‡ac   Duhee Bang,c   Se Won Bae,d   Hak Joong Kimb  and  Dae-Ro Ahn*ae  

* Corresponding authors

a The Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea
E-mail: drahn@kist.re.kr

b Department of Chemistry, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, Republic of Korea

c Department of Chemistry, College of Science, Yonsei University, Seoul, Republic of Korea

d Green Materials and Process Group, Korea Institute of Industrial Technology, Cheonan, Chungnam 31056, Republic of Korea

e Department of Biological Chemistry, KIST campus, University of Science and Technology (UST), Republic of Korea

Abstract

Although rolling circle amplification (RCA) is an efficient method to produce DNA materials for biomedical applications, it does not yield nano-sized products suitable for intracellular delivery. We here provide the ways to control the size of RCA products and show a potential application of the size-controlled DNA nanoparticles.

Graphical abstract: Biophysical and chemical handles to control the size of DNA nanoparticles produced by rolling circle amplification

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Article information

DOI
https://doi.org/10.1039/C6BM00296J
Article type
Communication
Submitted
28 Apr 2016
Accepted
16 Jul 2016
First published
27 Jul 2016

Biomater. Sci., 2016,4, 1314-1317

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Biophysical and chemical handles to control the size of DNA nanoparticles produced by rolling circle amplification

S. Y. Lee, K. Kim, D. Bang, S. W. Bae, H. J. Kim and D. Ahn, Biomater. Sci., 2016, 4, 1314 DOI: 10.1039/C6BM00296J

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