Detection of protein expression by MRI requires a high payload of Gd(III) per protein binding event. Presented here is a targeted AuDNA nanoparticle capable of delivering several hundred Gd(III) chelates to the HaloTag reporter protein. Incubating this particle with HaloTag-expressing cells produced a 9.4 contrast-to-noise ratio compared to non-expressing cells.
L. F. Vistain, M. W. Rotz, R. Rathore, A. T. Preslar and T. J. Meade, Chem. Commun., 2016, 52, 160 DOI: 10.1039/C5CC06565H
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