A signal-on split aptasensor for highly sensitive and specific detection of tumor cells based on FRET

Baoyin Yuan; Yu Zhou; Qiuping Guo; Kemin Wang; Xiaohai Yang; Xiangxian Meng; Jun Wan; Yuyu Tan; Zhixiang Huang; Qin Xie; Xiayu Zhao

doi:10.1039/C5CC08060F

A signal-on split aptasensor for highly sensitive and specific detection of tumor cells based on FRET†

Baoyin Yuan,‡^a Yu Zhou,‡^a Qiuping Guo,*^a Kemin Wang,*^a Xiaohai Yang,^a Xiangxian Meng,^a Jun Wan,^a Yuyu Tan,^a Zhixiang Huang,^a Qin Xie^a and Xiayu Zhao^a

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^a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Changsha, China
E-mail: kmwang@hnu.edu.cn, guoqping@126.com
Tel: +86-731-88821566

Abstract

We present here a signal-on fluorescence biosensor for highly sensitive and specific detection of tumor cells with a split aptamer based on fluorescence resonance energy transfer (FRET). This sensor holds considerable potential for simple, rapid, sensitive and specific tumor cell detection in early clinical diagnosis.

Chemical Communications

A signal-on split aptasensor for highly sensitive and specific detection of tumor cells based on FRET†

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A signal-on split aptasensor for highly sensitive and specific detection of tumor cells based on FRET

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