It has been over a half-century since Kornblum demonstrated the conversion of a primary nitroalkane to a carboxylic acid; addition of an amine results in carboxylic acid formation as well. We describe the formation of amides from terminal nitroalkanes in a two-step, one-pot reaction involving tandem halogenation/umpolung amide synthesis (UmAS).
K. E. Schwieter and J. N. Johnston, Chem. Commun., 2016, 52, 152 DOI: 10.1039/C5CC08415F
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