The topochemical synthesis of triazole-linked homobasic DNA

Abstract

Triazolyl-DNA (^TLDNA), a DNA-analog wherein phosphodiester units are replaced by triazole motifs, is of great interest. We have synthesized ^TLDNA oligomers by adopting the Topochemical Azide–Alkyne Cycloaddition (TAAC) reaction. A nucleoside decorated with the azide and alkyne units crystallized with the proximal placement of the azide and alkyne units of the adjacent molecules and underwent the TAAC reaction to form ^TLDNA oligomers.