Intracellular delivery of biomineralized monoclonal antibodies to combat viral infection

Zhiyong Song; Long Liu; Xiaoyu Wang; Yongqiang Deng; Qinggong Nian; Guangchuan Wang; Shunya Zhu; Xiaofeng Li; Hangyu Zhou; Tao Jiang; Xurong Xu; Ruikang Tang; Chengfeng Qin

doi:10.1039/C5CC09252C

Intracellular delivery of biomineralized monoclonal antibodies to combat viral infection†

Zhiyong Song,^ab Long Liu,^bc Xiaoyu Wang,^bd Yongqiang Deng,^b Qinggong Nian,^b Guangchuan Wang,^bd Shunya Zhu,^b Xiaofeng Li,^be Hangyu Zhou,^ab Tao Jiang,^be Xurong Xu,^ad Ruikang Tang*^ad and Chengfeng Qin*^bce

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* Corresponding authors

^a Center for Biomaterials and Bioparthways Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, P. R. China
E-mail: rtang@zju.edu.cn

^b Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. China
E-mail: qincf@bmi.ac.cn

^c Anhui Medical University, Hefei 230032, P. R. China

^d Qiushi Academy for Advanced Studies Zhejiang University, Hangzhou, Zhejiang, P. R. China

^e State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, China

Abstract

Conventional therapeutic monoclonal antibodies (mAbs) are invalid for intracellular viruses but by using in situ biomineralization treatment, they can be successfully delivered into cells to inhibit intracellular viral replication. This achievement significantly expands the applications of mAbs and provides a new intracellular strategy to control viral infections.

Chemical Communications

Intracellular delivery of biomineralized monoclonal antibodies to combat viral infection†

Abstract

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Intracellular delivery of biomineralized monoclonal antibodies to combat viral infection

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