Issue 9, 2016

Versatile process for the stereodiverse construction of 1,3-polyols: iterative chain elongation with chiral building blocks

Abstract

A versatile process for the construction of 1,3-polyols, a key structural element of polyketide-type natural products, is presented. The modular synthesis strategy involves the iterative chain elongation with novel four-carbon building blocks to access all possible stereoisomers of a growing 1,3-polyol chain. These chiral building blocks are designed to install four carbon atoms with two stereogenic centres by performing only four experimentally simple steps per elongation cycle, thus making these building blocks attractive for the realization of a universal platform from which to access a diverse range of polyketidic molecules.

Graphical abstract: Versatile process for the stereodiverse construction of 1,3-polyols: iterative chain elongation with chiral building blocks

Supplementary files

Article information

Article type
Communication
Submitted
10 Nov 2015
Accepted
04 Dec 2015
First published
17 Dec 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 1875-1878

Versatile process for the stereodiverse construction of 1,3-polyols: iterative chain elongation with chiral building blocks

A. Bredenkamp, M. Wegener, S. Hummel, A. P. Häring and S. F. Kirsch, Chem. Commun., 2016, 52, 1875 DOI: 10.1039/C5CC09328G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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