Issue 11, 2016
From the journal:

Chemical Communications

Photo-click construction of a targetable and activatable two-photon probe imaging protease in apoptosis†

Mi Zhou,a   Jing Hu,a   Mengmeng Zheng,a   Qinhua Song,b   Jinbo Li*a  and  Yan Zhang*a  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Science, Institute of Chemistry & BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, P. R. China
E-mail: njuzy@nju.edu.cn, jinboli@nju.edu.cn

b Department of Chemistry, Joint Laboratory of Green Synthetic Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China

Abstract

A photo-click reaction was used as an efficient method to construct two-photon fluorescent probes bearing two functional peptides for targeting and for protease cleavage respectively. The activatable two-photon probe constructed by this method was applied to two-photon imaging of caspase-3 both in cellular apoptosis and in tumor tissue.

Graphical abstract: Photo-click construction of a targetable and activatable two-photon probe imaging protease in apoptosis

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Article information

DOI
https://doi.org/10.1039/C5CC09973K
Article type
Communication
Submitted
04 Dec 2015
Accepted
22 Dec 2015
First published
22 Dec 2015

Chem. Commun., 2016,52, 2342-2345

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Photo-click construction of a targetable and activatable two-photon probe imaging protease in apoptosis

M. Zhou, J. Hu, M. Zheng, Q. Song, J. Li and Y. Zhang, Chem. Commun., 2016, 52, 2342 DOI: 10.1039/C5CC09973K

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