Issue 29, 2016
From the journal:

Chemical Communications

Coupling a DNA–ligand ensemble with Ag cluster formation for the label-free and ratiometric detection of intracellular biothiols†

Fangfang Cao,ab   Enguo Ju,ab   Chaoqun Liu,ab   Fang Pu,*a   Jinsong Ren*a  and  Xiaogang Qu*a  

* Corresponding authors

a Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China
E-mail: jren@ciac.ac.cn, xqu@ciac.ac.cn

b University of Chinese Academy of Sciences, Beijing 100039, China

Abstract

We have demonstrated the synthesis of a smart nanoprobe by coupling a DNA–ligand ensemble with Ag cluster formation that allows the label-free and ratiometric detection of intracellular biothiols with high sensitivity and selectivity as well as discrimination of normal cells and cancer cells.

Graphical abstract: Coupling a DNA–ligand ensemble with Ag cluster formation for the label-free and ratiometric detection of intracellular biothiols

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Article information

DOI
https://doi.org/10.1039/C5CC10606K
Article type
Communication
Submitted
28 Dec 2015
Accepted
14 Mar 2016
First published
14 Mar 2016

Chem. Commun., 2016,52, 5167-5170

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Coupling a DNA–ligand ensemble with Ag cluster formation for the label-free and ratiometric detection of intracellular biothiols

F. Cao, E. Ju, C. Liu, F. Pu, J. Ren and X. Qu, Chem. Commun., 2016, 52, 5167 DOI: 10.1039/C5CC10606K

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