Issue 23, 2016
From the journal:

Chemical Communications

Novel BODIPY-based Ru(ii) and Ir(iii) metalla-rectangles: cellular localization of compounds and their antiproliferative activities†

Gajendra Gupta,‡*a   Abhishek Das,‡b   Nikhil Baban Ghate,b   Takhyeon Kim,a   Ji Yeon Ryu, ORCID logo c   Junseong Lee,c   Nripendranath Mandal*b  and  Chang Yeon Lee*a  

* Corresponding authors

a Department of Energy and Chemical Engineering, Incheon National University, Incheon 406-772, Republic of Korea
E-mail: gjngupt@gmail.com, cylee@inu.ac.kr
Fax: +82-32-835-0797

b Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VIIM, Kolkata-700054, West Bengal, India
E-mail: mandaln@rediffmail.com

c Department of Chemistry, Chonnam National University, Gwangju 500-757, Republic of Korea

Abstract

The first examples of Ru(ii) and Ir(iii) metalla-rectangles [1]4+–[4]4+ containing a BODIPY-based linker are reported; some of these compounds exhibited highly selective anticancer activity and interact strongly with DNA as well as protein. The characteristic green fluorescence of a BODIPY ligand and associated aggregation-induced emission (AIE) permitted visualization of compounds inside the cells using confocal microscopy.

Graphical abstract: Novel BODIPY-based Ru(ii) and Ir(iii) metalla-rectangles: cellular localization of compounds and their antiproliferative activities

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Article information

DOI
https://doi.org/10.1039/C6CC00046K
Article type
Communication
Submitted
05 Jan 2016
Accepted
20 Jan 2016
First published
20 Jan 2016

Chem. Commun., 2016,52, 4274-4277

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Novel BODIPY-based Ru(II) and Ir(III) metalla-rectangles: cellular localization of compounds and their antiproliferative activities

G. Gupta, A. Das, N. B. Ghate, T. Kim, J. Y. Ryu, J. Lee, N. Mandal and C. Y. Lee, Chem. Commun., 2016, 52, 4274 DOI: 10.1039/C6CC00046K

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